Access Keys:
Skip to content (Access Key - 0)

DNA Replication

Versions Compared

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.
Comment: Migration of unmigrated content due to installation of a new plugin

...

Section
bordertrue
Column
width30%

This is an animation of an overview of DNA replication.

Column
width70%

   

Multimedia
height320
width480
nameDNA_replication1.swf
width480

 
 

Section
bordertrue
Column
width60%

Along a strand of DNA, replication begins at numerous origins of replication. There are several enzymes involved in the process of DNA replication. Helicases unwind the DNA double helix, single-strand binding proteins keep the strands separate while primases initiate replication, and DNA polymerase adds nucleotides to the unwound parent molecule. While the fundamentals of replication are simple, there is a feature of DNA structure that makes things a bit more complicated; the strands have opposite chemical polarities. This can be hard to comprehend because the strands seem identical. However, a close inspection reveals that the H-bonding that occurs between bases is only achieved if the strands have opposite polarities. This arrangement of strands is antiparallel, with one strand designated the 3'-to-5' strand and the other the 5'-to-3' strand (Fig. 4).

Column
width40%


Figure 4.  DNA structure. Note that the 3' end of one strand is aligned with the 5' end of the complementary strand. (Click to enlarge).

...

Section
bordertrue
Column
width30%

This is an animation of the steps of DNA replication.

Column
width70%



Multimedia
height480
width640
nameDNA_replication.swf
width640
autostarttrue

 

Errors during DNA Replication result in Mutations

...